Drug interactions
Dantrolene + Orphenadrine
Severity: Moderate
Dantrolene and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are muscle relaxants with sedative potential, and orphenadrine adds anticholinergic effects. Together they may cause pronounced drowsiness, dizziness and confusion, particularly in older adults.
What this interaction means in plain words
Dantrolene and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects with dantrolene's central sedation.
What to do
Avoid duplicating muscle relaxant therapy where possible, and monitor for oversedation and confusion. Use lower doses in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Orphenadrine?
MediHelp rates the interaction as moderate. Dantrolene and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are muscle relaxants with sedative potential, and orphenadrine adds anticholinergic effects. Together they may cause pronounced drowsiness, dizziness and confusion, particularly in older adults.
How serious is the interaction between Dantrolene and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicating muscle relaxant therapy where possible, and monitor for oversedation and confusion. Use lower doses in older patients.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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