Drug interactions
Dantrolene + Papaveretum
Severity: Moderate
Dantrolene and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, which depress the CNS and respiration. Combined with dantrolene, sedation and breathing depression may be intensified.
What this interaction means in plain words
Dantrolene and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism plus dantrolene's sedative effects.
What to do
Titrate the opioid cautiously and monitor sedation and respiratory rate. Avoid other sedatives and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Papaveretum?
MediHelp rates the interaction as moderate. Dantrolene and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine, which depress the CNS and respiration. Combined with dantrolene, sedation and breathing depression may be intensified.
How serious is the interaction between Dantrolene and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the opioid cautiously and monitor sedation and respiratory rate. Avoid other sedatives and alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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