Drug interactions
Dantrolene + Phenytoin
Severity: Moderate
Dantrolene and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces hepatic enzymes and may reduce dantrolene levels. Clinical effect of dantrolene could be diminished.
What this interaction means in plain words
Dantrolene and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing hepatic metabolism of dantrolene.
What to do
Monitor spasticity control or clinical response and raise the dantrolene dose if needed. Reassess dosing when phenytoin is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Dantrolene with Phenytoin?
MediHelp rates the interaction as moderate. Dantrolene and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces hepatic enzymes and may reduce dantrolene levels. Clinical effect of dantrolene could be diminished.
How serious is the interaction between Dantrolene and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spasticity control or clinical response and raise the dantrolene dose if needed. Reassess dosing when phenytoin is started or stopped.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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