Drug interactions
Dantrolene + Pholcodine
Severity: Minor
Dantrolene and Pholcodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid cough suppressant with mild sedative effects that may add to dantrolene drowsiness. At usual antitussive doses the effect is generally small.
What this interaction means in plain words
Dantrolene and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression through opioid receptor activity and dantrolene sedation.
What to do
Advise patients to watch for drowsiness and avoid driving if affected. Use the lowest effective antitussive dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Pholcodine?
MediHelp rates the interaction as minor. Dantrolene and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid cough suppressant with mild sedative effects that may add to dantrolene drowsiness. At usual antitussive doses the effect is generally small.
How serious is the interaction between Dantrolene and Pholcodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for drowsiness and avoid driving if affected. Use the lowest effective antitussive dose.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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