Drug interactions
Dantrolene + Quazepam
Severity: Moderate
Dantrolene and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting hypnotic benzodiazepine, and with dantrolene it can cause marked sedation, impaired coordination and next-day impairment. Falls and accidents are a particular risk.
What this interaction means in plain words
Dantrolene and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation by quazepam and dantrolene's sedative effects.
What to do
Use the lowest effective quazepam dose and monitor for daytime sedation and unsteadiness. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Quazepam?
MediHelp rates the interaction as moderate. Dantrolene and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting hypnotic benzodiazepine, and with dantrolene it can cause marked sedation, impaired coordination and next-day impairment. Falls and accidents are a particular risk.
How serious is the interaction between Dantrolene and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective quazepam dose and monitor for daytime sedation and unsteadiness. Counsel against driving and alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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