Drug interactions
Dantrolene + Remimazolam
Severity: Moderate
Dantrolene and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause central nervous system depression, and dantrolene commonly produces drowsiness and weakness. Used together during procedural sedation they may deepen sedation and impair breathing, with a risk of respiratory depression.
What this interaction means in plain words
Dantrolene and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from benzodiazepine GABA-A receptor agonism combined with the sedative and muscle-weakening effects of dantrolene.
What to do
Titrate remimazolam carefully and monitor oxygen saturation, respiratory rate and level of sedation continuously through recovery. Ensure airway equipment and personnel are available, and use lower doses when opioids or other sedatives are also given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Remimazolam
Frequently asked questions
Can I take Dantrolene with Remimazolam?
MediHelp rates the interaction as moderate. Dantrolene and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause central nervous system depression, and dantrolene commonly produces drowsiness and weakness. Used together during procedural sedation they may deepen sedation and impair breathing, with a risk of respiratory depression.
How serious is the interaction between Dantrolene and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and monitor oxygen saturation, respiratory rate and level of sedation continuously through recovery. Ensure airway equipment and personnel are available, and use lower doses when opioids or other sedatives are also given.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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