Drug interactions
Dantrolene + Rifampin
Severity: Moderate
Dantrolene and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of CYP3A4 and other enzymes, which may speed dantrolene metabolism and reduce its effect. This could lead to loss of efficacy in spasticity or malignant hyperthermia management.
What this interaction means in plain words
Dantrolene and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic and intestinal CYP3A4 by rifampin increases dantrolene clearance.
What to do
Monitor clinical response and increase the dantrolene dose if needed. Reassess dosing when rifampin is stopped, as induction wanes over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Rifampin?
MediHelp rates the interaction as moderate. Dantrolene and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong inducer of CYP3A4 and other enzymes, which may speed dantrolene metabolism and reduce its effect. This could lead to loss of efficacy in spasticity or malignant hyperthermia management.
How serious is the interaction between Dantrolene and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the dantrolene dose if needed. Reassess dosing when rifampin is stopped, as induction wanes over weeks.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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