Drug interactions
Dantrolene + Scullcap
Severity: Minor
Dantrolene and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is used traditionally as a sedative and may add to the drowsiness caused by dantrolene. Evidence is limited, and both agents may also carry hepatotoxic potential.
What this interaction means in plain words
Dantrolene and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedation; the herb's mechanism is not well established.
What to do
Counsel on additive drowsiness and avoid driving if affected. Consider avoiding the herb given dantrolene's hepatotoxicity risk, and monitor liver tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Scullcap?
MediHelp rates the interaction as minor. Dantrolene and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is used traditionally as a sedative and may add to the drowsiness caused by dantrolene. Evidence is limited, and both agents may also carry hepatotoxic potential.
How serious is the interaction between Dantrolene and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and avoid driving if affected. Consider avoiding the herb given dantrolene's hepatotoxicity risk, and monitor liver tests.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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