Drug interactions
Dantrolene + Sufentanil sl
Severity: Major
Dantrolene and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil cause respiratory depression and sedation, and dantrolene adds to CNS depression and muscle weakness. Concomitant use may lead to profound sedation, hypotension, respiratory depression and death.
What this interaction means in plain words
Dantrolene and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression between an opioid and a muscle relaxant.
What to do
Reserve the combination for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation level closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Sufentanil sl?
MediHelp rates the interaction as major. Dantrolene and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids such as sufentanil cause respiratory depression and sedation, and dantrolene adds to CNS depression and muscle weakness. Concomitant use may lead to profound sedation, hypotension, respiratory depression and death.
How serious is the interaction between Dantrolene and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation level closely.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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