Drug interactions
Dantrolene + Triclofos
Severity: Moderate
Dantrolene and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol depresses the CNS. With dantrolene, sedation and drowsiness may be increased.
What this interaction means in plain words
Dantrolene and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and reduce the hypnotic dose if needed. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Triclofos?
MediHelp rates the interaction as moderate. Dantrolene and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite trichloroethanol depresses the CNS. With dantrolene, sedation and drowsiness may be increased.
How serious is the interaction between Dantrolene and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the hypnotic dose if needed. Avoid alcohol and other sedatives.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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