Drug interactions
Dapagliflozin + Glyburide-metformin
Severity: Moderate
Dapagliflozin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin adds to the glucose-lowering effect of glyburide and increases the risk of hypoglycemia. Volume depletion may also occur.
What this interaction means in plain words
Dapagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from sulfonylurea-induced insulin secretion plus SGLT2-mediated glycosuria.
What to do
Consider reducing the glyburide dose when starting dapagliflozin. Monitor blood glucose and hydration status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Dapagliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin adds to the glucose-lowering effect of glyburide and increases the risk of hypoglycemia. Volume depletion may also occur.
How serious is the interaction between Dapagliflozin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting dapagliflozin. Monitor blood glucose and hydration status.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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