Drug interactions
Dapagliflozin + Insulin degludec
Severity: Moderate
Dapagliflozin and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin with insulin increases glucose lowering and the risk of hypoglycemia. SGLT2 inhibitors also carry a risk of ketoacidosis, which matters when insulin is reduced.
What this interaction means in plain words
Dapagliflozin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
SGLT2 inhibition increases urinary glucose excretion independent of insulin, adding to the effect of exogenous insulin.
What to do
Monitor blood glucose and consider a lower insulin dose when starting dapagliflozin, avoiding excessive reduction. Check ketones if symptoms of ketoacidosis occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin degludec?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin with insulin increases glucose lowering and the risk of hypoglycemia. SGLT2 inhibitors also carry a risk of ketoacidosis, which matters when insulin is reduced.
How serious is the interaction between Dapagliflozin and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider a lower insulin dose when starting dapagliflozin, avoiding excessive reduction. Check ketones if symptoms of ketoacidosis occur.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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