Drug interactions
Dapagliflozin + Insulin glargine-lixisenatide
Severity: Moderate
Dapagliflozin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin lowers glucose independently of insulin, so together they increase the risk of hypoglycemia. Volume depletion and diabetic ketoacidosis are also concerns when insulin doses are reduced.
What this interaction means in plain words
Dapagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition-induced glucosuria plus insulin and GLP-1 receptor agonism.
What to do
Consider lowering the insulin dose when adding dapagliflozin and monitor glucose. Educate the patient on ketoacidosis symptoms and avoid abrupt large insulin reductions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin lowers glucose independently of insulin, so together they increase the risk of hypoglycemia. Volume depletion and diabetic ketoacidosis are also concerns when insulin doses are reduced.
How serious is the interaction between Dapagliflozin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when adding dapagliflozin and monitor glucose. Educate the patient on ketoacidosis symptoms and avoid abrupt large insulin reductions.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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