Drug interactions
Dapagliflozin + Insulin isophane protamine human
Severity: Moderate
Dapagliflozin and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding dapagliflozin to insulin improves glycemic control but raises the chance of hypoglycemia, since the insulin dose may be too high once glucose falls through urinary excretion. Reducing insulin too aggressively, however, increases the risk of ketoacidosis, including euglycemic forms.
What this interaction means in plain words
Dapagliflozin and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin action and SGLT2 inhibition-driven glucosuria.
What to do
Consider a modest insulin dose reduction when starting dapagliflozin and monitor glucose frequently. Check ketones if the patient becomes unwell, and stop dapagliflozin during acute illness or fasting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Dapagliflozin and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding dapagliflozin to insulin improves glycemic control but raises the chance of hypoglycemia, since the insulin dose may be too high once glucose falls through urinary excretion. Reducing insulin too aggressively, however, increases the risk of ketoacidosis, including euglycemic forms.
How serious is the interaction between Dapagliflozin and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a modest insulin dose reduction when starting dapagliflozin and monitor glucose frequently. Check ketones if the patient becomes unwell, and stop dapagliflozin during acute illness or fasting.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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