Drug interactions
Dapagliflozin + Nateglinide
Severity: Moderate
Dapagliflozin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin lowers glucose through urinary excretion, and nateglinide stimulates insulin release. Used together, glucose lowering is additive and hypoglycemia becomes more likely, particularly when intake is poor.
What this interaction means in plain words
Dapagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from insulin secretion plus insulin-independent renal glucose excretion.
What to do
Monitor blood glucose after starting dapagliflozin and counsel the patient on hypoglycemia symptoms. Reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Nateglinide?
MediHelp rates the interaction as moderate. Dapagliflozin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin lowers glucose through urinary excretion, and nateglinide stimulates insulin release. Used together, glucose lowering is additive and hypoglycemia becomes more likely, particularly when intake is poor.
How serious is the interaction between Dapagliflozin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting dapagliflozin and counsel the patient on hypoglycemia symptoms. Reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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