Drug interactions
Dapagliflozin-metformin + Diazoxide
Severity: Moderate
Dapagliflozin-metformin and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral diazoxide causes hyperglycemia and directly opposes the glucose-lowering action of dapagliflozin and metformin. Diabetes control can deteriorate substantially.
What this interaction means in plain words
Dapagliflozin-metformin and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Diazoxide belongs to Miscellaneous.
Why it happens
Diazoxide opens pancreatic beta-cell KATP channels, which suppresses insulin secretion and raises blood glucose.
What to do
Monitor blood glucose frequently and increase antidiabetic therapy as needed. Reassess the dose if diazoxide is changed or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Diazoxide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Other interactions of Diazoxide
Frequently asked questions
Can I take Dapagliflozin-metformin with Diazoxide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral diazoxide causes hyperglycemia and directly opposes the glucose-lowering action of dapagliflozin and metformin. Diabetes control can deteriorate substantially.
How serious is the interaction between Dapagliflozin-metformin and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and increase antidiabetic therapy as needed. Reassess the dose if diazoxide is changed or stopped.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
