Drug interactions
Dapagliflozin-metformin + Doxepin
Severity: Minor
Dapagliflozin-metformin and Doxepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been associated with changes in glucose control, and in some patients may enhance hypoglycemia or alter appetite and weight. With metformin and dapagliflozin, which rarely cause hypoglycemia on their own, the effect is generally small. Clinical relevance is limited.
What this interaction means in plain words
Dapagliflozin-metformin and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Doxepin belongs to Dermatology.
Why it happens
Possible additive effect on glucose lowering through altered insulin sensitivity and appetite; the mechanism is not firmly established.
What to do
No dose change is usually required; check blood glucose when doxepin is started or stopped in patients with diabetes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Doxepin?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been associated with changes in glucose control, and in some patients may enhance hypoglycemia or alter appetite and weight. With metformin and dapagliflozin, which rarely cause hypoglycemia on their own, the effect is generally small. Clinical relevance is limited.
How serious is the interaction between Dapagliflozin-metformin and Doxepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; check blood glucose when doxepin is started or stopped in patients with diabetes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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