Drug interactions
Dapagliflozin-metformin + Dulaglutide
Severity: Minor
Dapagliflozin-metformin and Dulaglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining dulaglutide with dapagliflozin and metformin produces additive glucose lowering, which is often intended. Hypoglycemia risk is low unless a sulfonylurea or insulin is also used, and gastrointestinal effects with volume loss may occur.
What this interaction means in plain words
Dapagliflozin-metformin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Dulaglutide belongs to Endocrine.
Why it happens
Complementary pharmacodynamic actions of GLP-1 receptor agonism, SGLT2 inhibition and reduced hepatic glucose output.
What to do
Monitor glucose and hydration status, and reduce any concomitant insulin or sulfonylurea dose when adding dulaglutide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dapagliflozin-metformin with Dulaglutide?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining dulaglutide with dapagliflozin and metformin produces additive glucose lowering, which is often intended. Hypoglycemia risk is low unless a sulfonylurea or insulin is also used, and gastrointestinal effects with volume loss may occur.
How serious is the interaction between Dapagliflozin-metformin and Dulaglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and hydration status, and reduce any concomitant insulin or sulfonylurea dose when adding dulaglutide.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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