Drug interactions
Dapagliflozin-metformin + Famotidine
Severity: Minor
Dapagliflozin-metformin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may modestly raise metformin exposure by competing for renal tubular secretion. The effect is generally small and rarely clinically significant at usual doses.
What this interaction means in plain words
Dapagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) reduces metformin renal clearance.
What to do
No dose change usually needed; monitor glycemic response and for metformin adverse effects if renal function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Dapagliflozin-metformin with Famotidine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may modestly raise metformin exposure by competing for renal tubular secretion. The effect is generally small and rarely clinically significant at usual doses.
How serious is the interaction between Dapagliflozin-metformin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change usually needed; monitor glycemic response and for metformin adverse effects if renal function is reduced.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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