Drug interactions
Dapagliflozin-metformin + Fluoxetine
Severity: Minor
Dapagliflozin-metformin and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may enhance insulin sensitivity and lower blood glucose, which can add to the effect of dapagliflozin-metformin. Hypoglycemia is uncommon with these agents but has been reported, mainly with insulin or sulfonylureas.
What this interaction means in plain words
Dapagliflozin-metformin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Fluoxetine belongs to Central Nervous System.
Why it happens
SSRIs may improve insulin sensitivity and alter glucose counter-regulation, giving additive glucose lowering.
What to do
Monitor blood glucose when fluoxetine is started, adjusted or stopped, and reduce antidiabetic doses only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Fluoxetine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine may enhance insulin sensitivity and lower blood glucose, which can add to the effect of dapagliflozin-metformin. Hypoglycemia is uncommon with these agents but has been reported, mainly with insulin or sulfonylureas.
How serious is the interaction between Dapagliflozin-metformin and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluoxetine is started, adjusted or stopped, and reduce antidiabetic doses only if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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