Drug interactions
Dapagliflozin-metformin + Folic acid
Severity: Minor
Dapagliflozin-metformin and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin has been associated with lower serum folate in some studies, though clinical deficiency is uncommon. Folic acid supplementation does not affect metformin efficacy.
What this interaction means in plain words
Dapagliflozin-metformin and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Folic acid belongs to Miscellaneous.
Why it happens
The mechanism is not established; altered intestinal absorption has been proposed.
What to do
No routine action needed; check folate if macrocytic anemia occurs and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Folic acid?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin has been associated with lower serum folate in some studies, though clinical deficiency is uncommon. Folic acid supplementation does not affect metformin efficacy.
How serious is the interaction between Dapagliflozin-metformin and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; check folate if macrocytic anemia occurs and supplement if low.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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