Drug interactions
Dapagliflozin-metformin + Histrelin
Severity: Minor
Dapagliflozin-metformin and Histrelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GnRH agonists such as histrelin can reduce glucose tolerance and insulin sensitivity, which may worsen glycemic control. The effect develops during long-term therapy.
What this interaction means in plain words
Dapagliflozin-metformin and Histrelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Histrelin belongs to Musculoskeletal.
Why it happens
Sex hormone suppression alters insulin sensitivity, giving a pharmacodynamic opposition to the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c during histrelin therapy. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Histrelin?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Histrelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. GnRH agonists such as histrelin can reduce glucose tolerance and insulin sensitivity, which may worsen glycemic control. The effect develops during long-term therapy.
How serious is the interaction between Dapagliflozin-metformin and Histrelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during histrelin therapy. Adjust antidiabetic therapy as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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