Drug interactions
Dapagliflozin-metformin + Levofloxacin
Severity: Moderate
Dapagliflozin-metformin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can cause hypoglycemia or hyperglycemia in patients with diabetes, and labeling warns of this risk. Severe cases occur mostly with insulin or sulfonylureas, but older or renally impaired patients are at greater risk.
What this interaction means in plain words
Dapagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, leading to unpredictable dysglycemia.
What to do
Monitor blood glucose during the antibiotic course and educate the patient about hypoglycemia symptoms; discontinue levofloxacin if marked dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Levofloxacin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can cause hypoglycemia or hyperglycemia in patients with diabetes, and labeling warns of this risk. Severe cases occur mostly with insulin or sulfonylureas, but older or renally impaired patients are at greater risk.
How serious is the interaction between Dapagliflozin-metformin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and educate the patient about hypoglycemia symptoms; discontinue levofloxacin if marked dysglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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