Drug interactions
Dapagliflozin-metformin + Levothyroxine
Severity: Moderate
Dapagliflozin-metformin and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases hepatic glucose production and metabolic rate, which can worsen glycemic control, especially if the dose is excessive. Changes in levothyroxine dose may therefore alter antidiabetic requirements.
What this interaction means in plain words
Dapagliflozin-metformin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Levothyroxine belongs to Endocrine.
Why it happens
Thyroid hormone raises glucose production and turnover, opposing the glucose-lowering effect of antidiabetic drugs.
What to do
Monitor glucose and HbA1c when starting or changing levothyroxine dose, and keep TSH in range to avoid over-replacement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Levothyroxine
Frequently asked questions
Can I take Dapagliflozin-metformin with Levothyroxine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases hepatic glucose production and metabolic rate, which can worsen glycemic control, especially if the dose is excessive. Changes in levothyroxine dose may therefore alter antidiabetic requirements.
How serious is the interaction between Dapagliflozin-metformin and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when starting or changing levothyroxine dose, and keep TSH in range to avoid over-replacement.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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