Drug interactions
Dapagliflozin-metformin + Linezolid
Severity: Moderate
Dapagliflozin-metformin and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in patients taking antidiabetic drugs, and it can also cause lactic acidosis through mitochondrial toxicity. Both are relevant when metformin is used.
What this interaction means in plain words
Dapagliflozin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Linezolid's weak MAO inhibition and mitochondrial toxicity may enhance glucose lowering and add to metformin-associated lactic acidosis risk.
What to do
Monitor blood glucose during linezolid therapy and watch for signs of lactic acidosis such as nausea, malaise or rapid breathing; reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Linezolid?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in patients taking antidiabetic drugs, and it can also cause lactic acidosis through mitochondrial toxicity. Both are relevant when metformin is used.
How serious is the interaction between Dapagliflozin-metformin and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and watch for signs of lactic acidosis such as nausea, malaise or rapid breathing; reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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