Drug interactions
Dapagliflozin-metformin + Maprotiline
Severity: Minor
Dapagliflozin-metformin and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants such as maprotiline may alter glucose control, occasionally enhancing hypoglycemia in patients using antidiabetic drugs. The effect is unpredictable and usually small.
What this interaction means in plain words
Dapagliflozin-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; effects on insulin sensitivity and appetite have been proposed.
What to do
Monitor blood glucose when starting or stopping maprotiline; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Maprotiline?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antidepressants such as maprotiline may alter glucose control, occasionally enhancing hypoglycemia in patients using antidiabetic drugs. The effect is unpredictable and usually small.
How serious is the interaction between Dapagliflozin-metformin and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping maprotiline; no routine dose change is needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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