Drug interactions
Dapagliflozin-metformin + Nizatidine
Severity: Minor
Dapagliflozin-metformin and Nizatidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nizatidine may raise metformin concentrations by reducing its renal tubular secretion. Higher metformin exposure could increase adverse effects, particularly with renal impairment.
What this interaction means in plain words
Dapagliflozin-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Competition for renal tubular cation transporters (OCT2/MATE) reduces metformin clearance.
What to do
No routine adjustment is needed; monitor glycemic control and renal function, and reduce metformin dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Nizatidine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Nizatidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nizatidine may raise metformin concentrations by reducing its renal tubular secretion. Higher metformin exposure could increase adverse effects, particularly with renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Nizatidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor glycemic control and renal function, and reduce metformin dose if adverse effects emerge.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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