Drug interactions
Dapagliflozin-metformin + Quetiapine
Severity: Moderate
Dapagliflozin-metformin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is linked to weight gain, insulin resistance and hyperglycaemia, which can work against the glucose-lowering effect of dapagliflozin-metformin. Diabetic control may deteriorate, particularly in the first months of antipsychotic therapy.
What this interaction means in plain words
Dapagliflozin-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Atypical antipsychotics can impair insulin sensitivity and promote weight gain, opposing antidiabetic drug effects (pharmacodynamic antagonism).
What to do
Monitor fasting glucose and HbA1c at baseline and periodically during quetiapine therapy. Intensify the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Quetiapine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is linked to weight gain, insulin resistance and hyperglycaemia, which can work against the glucose-lowering effect of dapagliflozin-metformin. Diabetic control may deteriorate, particularly in the first months of antipsychotic therapy.
How serious is the interaction between Dapagliflozin-metformin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically during quetiapine therapy. Intensify the antidiabetic regimen if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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