Drug interactions
Dapagliflozin-metformin + Quinidine
Severity: Moderate
Dapagliflozin-metformin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a cationic drug that competes with metformin for renal tubular secretion and may raise metformin exposure. Higher levels could increase gastrointestinal effects and, rarely in predisposed patients, the risk of lactic acidosis.
What this interaction means in plain words
Dapagliflozin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits renal organic cation transporters (OCT2) and MATE, reducing tubular secretion of metformin.
What to do
Monitor glycaemic response, renal function and signs of metformin toxicity. Reduce the metformin dose if adverse effects appear or renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Quinidine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a cationic drug that competes with metformin for renal tubular secretion and may raise metformin exposure. Higher levels could increase gastrointestinal effects and, rarely in predisposed patients, the risk of lactic acidosis.
How serious is the interaction between Dapagliflozin-metformin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycaemic response, renal function and signs of metformin toxicity. Reduce the metformin dose if adverse effects appear or renal function is impaired.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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