Drug interactions
Dapagliflozin-metformin + Ritonavir
Severity: Moderate
Dapagliflozin-metformin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir and other protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin. Glycemic control may deteriorate, especially during long-term therapy.
What this interaction means in plain words
Dapagliflozin-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism oppose the antidiabetic effect.
What to do
Monitor blood glucose and HbA1c regularly after starting ritonavir and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Ritonavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir and other protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin. Glycemic control may deteriorate, especially during long-term therapy.
How serious is the interaction between Dapagliflozin-metformin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly after starting ritonavir and intensify antidiabetic therapy if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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