Drug interactions
Dapagliflozin-metformin + Sertraline
Severity: Minor
Dapagliflozin-metformin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as sertraline may improve insulin sensitivity and in some patients lower blood glucose, which can add to the effect of antidiabetic drugs. Hypoglycaemia is uncommon with metformin and dapagliflozin, but glucose may fall more than expected.
What this interaction means in plain words
Dapagliflozin-metformin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline may enhance insulin sensitivity, producing an additive glucose-lowering effect (pharmacodynamic synergism).
What to do
Be aware of lower glucose values after starting sertraline and monitor blood glucose. Reduce the antidiabetic dose if hypoglycaemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Sertraline?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as sertraline may improve insulin sensitivity and in some patients lower blood glucose, which can add to the effect of antidiabetic drugs. Hypoglycaemia is uncommon with metformin and dapagliflozin, but glucose may fall more than expected.
How serious is the interaction between Dapagliflozin-metformin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of lower glucose values after starting sertraline and monitor blood glucose. Reduce the antidiabetic dose if hypoglycaemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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