Drug interactions
Dapagliflozin-metformin + Tafenoquine
Severity: Moderate
Dapagliflozin-metformin and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal cation transporters in vitro, which can reduce metformin clearance and raise its plasma exposure. Higher metformin levels increase the risk of gastrointestinal intolerance and, in susceptible patients, lactic acidosis.
What this interaction means in plain words
Dapagliflozin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Tafenoquine belongs to Anti Parasitic.
Why it happens
Tafenoquine inhibits OCT2 and MATE transporters, reducing renal tubular secretion of metformin.
What to do
Avoid coadministration where possible; if tafenoquine is required, monitor glucose, renal function and signs of metformin toxicity. Consider reducing the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Tafenoquine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits renal cation transporters in vitro, which can reduce metformin clearance and raise its plasma exposure. Higher metformin levels increase the risk of gastrointestinal intolerance and, in susceptible patients, lactic acidosis.
How serious is the interaction between Dapagliflozin-metformin and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; if tafenoquine is required, monitor glucose, renal function and signs of metformin toxicity. Consider reducing the metformin dose if adverse effects appear.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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