Drug interactions
Dapagliflozin-metformin + Tranylcypromine
Severity: Moderate
Dapagliflozin-metformin and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance the glucose-lowering effect of antidiabetic drugs, which can cause hypoglycemia. Tranylcypromine's effect on metformin specifically is not well characterized.
What this interaction means in plain words
Dapagliflozin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
Mechanism not firmly established; MAO inhibition may potentiate glucose lowering.
What to do
Monitor blood glucose when starting or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Tranylcypromine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may enhance the glucose-lowering effect of antidiabetic drugs, which can cause hypoglycemia. Tranylcypromine's effect on metformin specifically is not well characterized.
How serious is the interaction between Dapagliflozin-metformin and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tranylcypromine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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