Drug interactions
Daprodustat + Losartan
Severity: Moderate
Daprodustat and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is cleared by CYP2C8, and losartan has been classed as a CYP2C8 inhibitor in this context. Higher daprodustat exposure may increase the risk of adverse effects such as thrombotic events or excessive hemoglobin rise.
What this interaction means in plain words
Daprodustat and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C8-mediated daprodustat metabolism.
What to do
Follow daprodustat labeling and reduce the starting dose when coadministered with moderate CYP2C8 inhibitors. Monitor hemoglobin and adjust dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Losartan?
MediHelp rates the interaction as moderate. Daprodustat and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daprodustat is cleared by CYP2C8, and losartan has been classed as a CYP2C8 inhibitor in this context. Higher daprodustat exposure may increase the risk of adverse effects such as thrombotic events or excessive hemoglobin rise.
How serious is the interaction between Daprodustat and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow daprodustat labeling and reduce the starting dose when coadministered with moderate CYP2C8 inhibitors. Monitor hemoglobin and adjust dose.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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