Drug interactions
Daprodustat + Rosiglitazone
Severity: Moderate
Daprodustat and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone is a CYP2C8 substrate and inhibitor of modest strength, and daprodustat is cleared by CYP2C8. Inhibiting this pathway may raise daprodustat exposure and increase risk of excessive hemoglobin rise and thrombotic events.
What this interaction means in plain words
Daprodustat and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8-mediated daprodustat metabolism raises its exposure.
What to do
Reduce the daprodustat starting dose per labeling when a CYP2C8 inhibitor is used, and monitor hemoglobin. Readjust the dose when the inhibitor is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Rosiglitazone?
MediHelp rates the interaction as moderate. Daprodustat and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rosiglitazone is a CYP2C8 substrate and inhibitor of modest strength, and daprodustat is cleared by CYP2C8. Inhibiting this pathway may raise daprodustat exposure and increase risk of excessive hemoglobin rise and thrombotic events.
How serious is the interaction between Daprodustat and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the daprodustat starting dose per labeling when a CYP2C8 inhibitor is used, and monitor hemoglobin. Readjust the dose when the inhibitor is started or stopped.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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