Drug interactions
Dapsone + Didanosine
Severity: Moderate
Dapsone and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause peripheral neuropathy, so combined use may increase the risk or severity of nerve damage. Didanosine formulations containing buffer may also reduce the absorption of dapsone.
What this interaction means in plain words
Dapsone and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Additive neurotoxicity; buffered didanosine may raise gastric pH and reduce dapsone absorption.
What to do
Avoid the combination where alternatives exist and monitor for neuropathy symptoms; if the buffered formulation is used, separate doses by at least 2 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Frequently asked questions
Can I take Dapsone with Didanosine?
MediHelp rates the interaction as moderate. Dapsone and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause peripheral neuropathy, so combined use may increase the risk or severity of nerve damage. Didanosine formulations containing buffer may also reduce the absorption of dapsone.
How serious is the interaction between Dapsone and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist and monitor for neuropathy symptoms; if the buffered formulation is used, separate doses by at least 2 hours.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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