Drug interactions
Dapsone + Griseofulvin
Severity: Minor
Dapsone and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of hepatic enzymes and could modestly lower dapsone exposure. No meaningful loss of dapsone efficacy has been well documented.
What this interaction means in plain words
Dapsone and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Griseofulvin belongs to Anti Fungals.
Why it happens
Possible weak induction of CYP3A4-mediated dapsone metabolism by griseofulvin.
What to do
No routine action is needed; assess clinical response to dapsone if treatment is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Griseofulvin
Frequently asked questions
Can I take Dapsone with Griseofulvin?
MediHelp rates the interaction as minor. Dapsone and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of hepatic enzymes and could modestly lower dapsone exposure. No meaningful loss of dapsone efficacy has been well documented.
How serious is the interaction between Dapsone and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; assess clinical response to dapsone if treatment is prolonged.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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