Drug interactions
Dapsone + Istradefylline
Severity: Moderate
Dapsone and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline increases exposure to CYP3A4 substrates, which could raise dapsone concentrations. This effect was not seen at 20 mg daily.
What this interaction means in plain words
Dapsone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, reducing dapsone metabolism.
What to do
Monitor CBC and methemoglobin symptoms, especially if istradefylline 40 mg daily is used; consider dapsone dose reduction if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Dapsone with Istradefylline?
MediHelp rates the interaction as moderate. Dapsone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily istradefylline increases exposure to CYP3A4 substrates, which could raise dapsone concentrations. This effect was not seen at 20 mg daily.
How serious is the interaction between Dapsone and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CBC and methemoglobin symptoms, especially if istradefylline 40 mg daily is used; consider dapsone dose reduction if toxicity appears.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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