Drug interactions
Dapsone + Ivosidenib
Severity: Moderate
Dapsone and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower dapsone concentrations. Reduced exposure could weaken prophylactic or therapeutic effect. The magnitude is uncertain.
What this interaction means in plain words
Dapsone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing dapsone clearance.
What to do
Monitor for loss of dapsone efficacy, or use alternative prophylaxis such as atovaquone if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Dapsone with Ivosidenib?
MediHelp rates the interaction as moderate. Dapsone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower dapsone concentrations. Reduced exposure could weaken prophylactic or therapeutic effect. The magnitude is uncertain.
How serious is the interaction between Dapsone and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of dapsone efficacy, or use alternative prophylaxis such as atovaquone if appropriate.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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