Drug interactions
Dapsone + Larotrectinib
Severity: Minor
Dapsone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, so a small rise in dapsone exposure is theoretically possible. Clinical significance is unknown.
What this interaction means in plain words
Dapsone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4, though this is not well established for dapsone.
What to do
No empiric adjustment is needed. Monitor for dapsone adverse effects during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dapsone with Larotrectinib?
MediHelp rates the interaction as minor. Dapsone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, so a small rise in dapsone exposure is theoretically possible. Clinical significance is unknown.
How serious is the interaction between Dapsone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed. Monitor for dapsone adverse effects during co-therapy.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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