Drug interactions
Dapsone + Nifedipine
Severity: Minor
Dapsone and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is mainly a CYP3A4 substrate with weak inhibitory effect, so any rise in dapsone levels is unlikely to be meaningful. No clinically important interaction has been established.
What this interaction means in plain words
Dapsone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Nifedipine belongs to Cardiovascular.
Why it happens
Theoretical weak CYP3A4 competition; not established clinically.
What to do
No specific action required beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Nifedipine
Frequently asked questions
Can I take Dapsone with Nifedipine?
MediHelp rates the interaction as minor. Dapsone and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is mainly a CYP3A4 substrate with weak inhibitory effect, so any rise in dapsone levels is unlikely to be meaningful. No clinically important interaction has been established.
How serious is the interaction between Dapsone and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action required beyond routine monitoring.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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