Drug interactions
Dapsone + Nilotinib
Severity: Minor
Dapsone and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and could modestly raise dapsone concentrations, potentially increasing methemoglobinemia and hemolysis. Nilotinib also causes myelosuppression, which may add to hematologic effects.
What this interaction means in plain words
Dapsone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Nilotinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by nilotinib reducing dapsone metabolism, with additive hematologic toxicity.
What to do
Monitor complete blood count and watch for signs of methemoglobinemia during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Dapsone with Nilotinib?
MediHelp rates the interaction as minor. Dapsone and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP3A4 and could modestly raise dapsone concentrations, potentially increasing methemoglobinemia and hemolysis. Nilotinib also causes myelosuppression, which may add to hematologic effects.
How serious is the interaction between Dapsone and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count and watch for signs of methemoglobinemia during co-therapy.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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