Drug interactions
Dapsone + Quinine
Severity: Moderate
Dapsone and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and dapsone can cause oxidative hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency. Combined use may increase the risk of hemolytic anemia.
What this interaction means in plain words
Dapsone and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Quinine belongs to Anti Parasitic.
Why it happens
Additive oxidative stress to red blood cells causing hemolysis and methemoglobin formation.
What to do
Check G6PD status before use and monitor hemoglobin and signs of hemolysis or methemoglobinemia. Prefer an alternative if G6PD deficiency is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Dapsone with Quinine?
MediHelp rates the interaction as moderate. Dapsone and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both quinine and dapsone can cause oxidative hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency. Combined use may increase the risk of hemolytic anemia.
How serious is the interaction between Dapsone and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check G6PD status before use and monitor hemoglobin and signs of hemolysis or methemoglobinemia. Prefer an alternative if G6PD deficiency is present.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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