Drug interactions
Dapsone + Valganciclovir
Severity: Moderate
Dapsone and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which is myelosuppressive, and dapsone can cause hemolysis and hematologic toxicity. Combined use may increase the risk of anemia and neutropenia.
What this interaction means in plain words
Dapsone and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Valganciclovir belongs to Anti Virals.
Why it happens
Additive hematologic toxicity from ganciclovir (active metabolite) and dapsone.
What to do
Monitor complete blood count regularly during co-therapy. Reduce or interrupt a drug if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Valganciclovir
Frequently asked questions
Can I take Dapsone with Valganciclovir?
MediHelp rates the interaction as moderate. Dapsone and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valganciclovir is converted to ganciclovir, which is myelosuppressive, and dapsone can cause hemolysis and hematologic toxicity. Combined use may increase the risk of anemia and neutropenia.
How serious is the interaction between Dapsone and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count regularly during co-therapy. Reduce or interrupt a drug if significant cytopenias develop.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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