Drug interactions
Daridorexant + Diazepam
Severity: Moderate
Daridorexant and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with an orexin receptor antagonist produces additive sedation and may impair next-day alertness, driving and coordination. Risk is greater at higher doses and in older adults.
What this interaction means in plain words
Daridorexant and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from GABA-A modulation and orexin receptor antagonism.
What to do
Avoid combining unless necessary and use the lowest effective doses. Counsel on daytime impairment and consider daridorexant dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Diazepam?
MediHelp rates the interaction as moderate. Daridorexant and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with an orexin receptor antagonist produces additive sedation and may impair next-day alertness, driving and coordination. Risk is greater at higher doses and in older adults.
How serious is the interaction between Daridorexant and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless necessary and use the lowest effective doses. Counsel on daytime impairment and consider daridorexant dose reduction.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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