Drug interactions
Daridorexant + Efavirenz
Severity: Moderate
Daridorexant and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can lower daridorexant concentrations, likely reducing its effect on insomnia.
What this interaction means in plain words
Daridorexant and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing daridorexant metabolism.
What to do
Avoid use with strong or moderate CYP3A4 inducers per labeling; consider a different insomnia treatment or reassess efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Efavirenz?
MediHelp rates the interaction as moderate. Daridorexant and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can lower daridorexant concentrations, likely reducing its effect on insomnia.
How serious is the interaction between Daridorexant and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with strong or moderate CYP3A4 inducers per labeling; consider a different insomnia treatment or reassess efficacy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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