Drug interactions
Daridorexant + Erythromycin
Severity: Moderate
Daridorexant and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin raises daridorexant exposure, increasing risk of next-day somnolence and impaired driving ability.
What this interaction means in plain words
Daridorexant and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 metabolism of daridorexant.
What to do
Do not exceed daridorexant 25 mg per night while on erythromycin. Counsel about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Erythromycin?
MediHelp rates the interaction as moderate. Daridorexant and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin raises daridorexant exposure, increasing risk of next-day somnolence and impaired driving ability.
How serious is the interaction between Daridorexant and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed daridorexant 25 mg per night while on erythromycin. Counsel about next-day drowsiness.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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