Drug interactions
Daridorexant + Imipramine
Severity: Moderate
Daridorexant and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen sedation and impair psychomotor performance, attention and memory. The effect may persist into the next day and raises the risk of falls and accidents.
What this interaction means in plain words
Daridorexant and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism combined with the sedating antihistaminic and anticholinergic effects of imipramine.
What to do
Start daridorexant at the lowest dose and reassess the need for both agents if daytime drowsiness occurs. Counsel the patient about driving and other tasks requiring alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Imipramine?
MediHelp rates the interaction as moderate. Daridorexant and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen sedation and impair psychomotor performance, attention and memory. The effect may persist into the next day and raises the risk of falls and accidents.
How serious is the interaction between Daridorexant and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start daridorexant at the lowest dose and reassess the need for both agents if daytime drowsiness occurs. Counsel the patient about driving and other tasks requiring alertness.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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