Drug interactions
Daridorexant + Lorazepam
Severity: Moderate
Daridorexant and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taken together, the two drugs have additive sedative effects that can impair next-day alertness, coordination and driving.
What this interaction means in plain words
Daridorexant and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and GABA-A potentiation.
What to do
Use the lowest effective doses and avoid combining where possible. Counsel on daytime impairment and falls risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lorazepam?
MediHelp rates the interaction as moderate. Daridorexant and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taken together, the two drugs have additive sedative effects that can impair next-day alertness, coordination and driving.
How serious is the interaction between Daridorexant and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid combining where possible. Counsel on daytime impairment and falls risk.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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