Drug interactions
Daridorexant + Lorlatinib
Severity: Moderate
Daridorexant and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A and may reduce daridorexant exposure, causing loss of hypnotic effect. Daridorexant labeling advises against use with CYP3A inducers.
What this interaction means in plain words
Daridorexant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing daridorexant metabolism.
What to do
Avoid combining and consider a non-CYP3A-dependent insomnia treatment. If used, monitor for insufficient sleep response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lorlatinib?
MediHelp rates the interaction as moderate. Daridorexant and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A and may reduce daridorexant exposure, causing loss of hypnotic effect. Daridorexant labeling advises against use with CYP3A inducers.
How serious is the interaction between Daridorexant and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining and consider a non-CYP3A-dependent insomnia treatment. If used, monitor for insufficient sleep response.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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